Open AccessCytomegalovirus-specific responses of CD38+ memory T cells are skewed towards IFN-γ and dissociated from CD154 in HIV-1 infection
Author(s) -
Gustavo Olvera-García,
Enrique Espinosa,
Scott F. Sieg,
Michael M. Lederman
Publication year - 2014
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000162
Subject(s) - cd154 , cd38 , immunology , memory t cell , cd40 , biology , t cell , cytokine , cytotoxic t cell , medicine , immune system , stem cell , in vitro , microbiology and biotechnology , biochemistry , cd34
Despite the strong correlation of T-cell CD38 expression with HIV disease progression, evidence linking CD38 expression and dysfunction at the single cell level is scant. Since CD38⁺ memory CD4⁺ T cells, especially those from HIV-infected persons, fail to induce CD154 (CD40L) while responding to a superantigen with interferon (IFN)-γ or interleukin (IL)-2, we aimed to determine if recall responses to cytomegalovirus (CMV) were similarly affected in the CD38⁺ memory CD4⁺ T-cell subpopulation.