Open AccessIncreased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection
Author(s) -
CS Palmer,
Matías Ostrowski,
Maëlenn Gouillou,
Ling-Ling Tsai,
Di Yu,
Jingling Zhou,
DC Henstridge,
Anna Maisa,
AC Hearps,
Sharon R. Lewin,
Alan Landay,
Anthony Jaworowski,
JM McCune,
Suzanne Crowe
Publication year - 2014
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000128
Subject(s) - glut1 , glucose transporter , cd38 , glucose transporter type 1 , cd8 , biology , t cell , flow cytometry , glucose uptake , immune system , immunology , medicine , endocrinology , microbiology and biotechnology , stem cell , insulin , cd34
Glucose metabolism plays a fundamental role in supporting the growth, proliferation and effector functions of T cells. We investigated the impact of HIV infection on key processes that regulate glucose uptake and metabolism in primary CD4 and CD8 T cells.