Open AccessDifferential expression of the alternatively spliced OPRM1 isoform μ-opioid receptor-1K in HIV-infected individuals
Author(s) -
Seth M. Dever,
Blair N. Costin,
Ruqiang Xu,
Nazira ElHage,
Joyce Balinang,
Alexander Samoshkin,
Megan A. O’Brien,
MaryPeace McRae,
Luda Diatchenko,
Pamela E. Knapp,
Kurt F. Hauser
Publication year - 2014
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000113
Subject(s) - biology , flna , alternative splicing , microbiology and biotechnology , gene isoform , cell , gene , genetics , filamin , cytoskeleton
We previously examined the expression of specific C-terminal μ-opioid receptor (MOR) splice variants in human central nervous system cell types and HIV-infected brain tissue from individuals with neurocognitive impairment ± HIV encephalitis (HIVE). In the present study, we examined the N-terminal splice variant MOR-1K, which mediates excitatory cellular signaling.