Open AccessSerum Concentrations and Pharmacokinetics of Tranexamic Acid after Two Means of Topical Administration in Massive Weight Loss Skin-Reducing Surgery
Author(s) -
Kjersti Ausen,
Hilde Pleym,
Jiayin Liu,
Solfrid Hegstad,
Håvard Bersås Nordgård,
Ivan Pavlović,
Olav Spigset
Publication year - 2019
Publication title -
plastic and reconstructive surgery/psef cd journals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.841
H-Index - 179
eISSN - 1076-5751
pISSN - 0032-1052
DOI - 10.1097/prs.0000000000005620
Subject(s) - tranexamic acid , medicine , anesthesia , bolus (digestion) , pharmacokinetics , intravenous bolus , adverse effect , surgery , blood loss , pharmacology
Topical administration of tranexamic acid to reduce bleeding is receiving increasing attention, as it is inexpensive, simple, and possibly beneficial in most surgery. Concerns regarding potential systemic adverse effects such as thromboembolic events and seizures may prevent general use of tranexamic acid. Although serum concentrations after topical application are assumed to be low, proper pharmacokinetic studies of tranexamic acid after topical application are lacking.