Open AccessImage-Based Noninvasive Evaluation of Colorectal Mucosal Injury in Sheep After Topical Application of Microbicides
Author(s) -
Kathleen L. Vincent,
Gracie Vargas,
Nigel Bourne,
Valerie Galvan-Turner,
Jamal I. Saada,
Gabriel H. Lee,
Elena Sbrana,
Massoud Motamedi
Publication year - 2013
Publication title -
sexually transmitted diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 105
eISSN - 1537-4521
pISSN - 0148-5717
DOI - 10.1097/olq.0000000000000039
Subject(s) - medicine , colonoscopy , optical coherence tomography , rectum , microbicide , vagina , submucosa , colorectal cancer , pathology , radiology , surgery , cancer , human immunodeficiency virus (hiv) , family medicine
Successful development of topical rectal microbicides requires preclinical evaluation in suitable large animal models. Our previous studies have demonstrated the benefits of high-resolution optical coherence tomography (OCT) to visualize subclinical microbicide toxicity in the sheep vagina. In the current study, we evaluated the potential application of colonoscopy and OCT to visualize and quantify the effects of topical products on sheep colorectal tissue, as assessed by advanced imaging techniques.