Open Accessβ-Lactams
Author(s) -
Rúben Fernandes,
Paula Amador,
Cristina Prudêncio
Publication year - 2012
Publication title -
reviews in medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.243
H-Index - 27
eISSN - 1473-5601
pISSN - 0954-139X
DOI - 10.1097/mrm.0b013e3283587727
Subject(s) - cephalosporin , microbiology and biotechnology , penicillin , antibiotics , chemistry , broad spectrum , notice , staphylococcus aureus , antibiotic resistance , computational biology , bacteria , biology , combinatorial chemistry , genetics , political science , law
This synopsis summarizes the key chemical and bacteriological characteristics of
β-lactams, penicillins, cephalosporins, carbanpenems, monobactams and others.
Particular notice is given to first-generation to fifth-generation cephalosporins. This
reviewalso summarizes the main resistancemechanism to antibiotics, focusing particular
attention to those conferring resistance to broad-spectrum cephalosporins by means of
production of emerging cephalosporinases (extended-spectrum β-lactamases and AmpC
β-lactamases), target alteration (penicillin-binding proteins from methicillin-resistant
Staphylococcus aureus) and membrane transporters that pump β-lactams out of the
bacterial cell
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