Open AccessNewborn Lamb as a New Model for Studying Gastroesophageal Reflux
Author(s) -
Djeddi Djamal,
Samson Nathalie,
Boudaa Nadia,
Praud JeanPaul
Publication year - 2012
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0b013e318263cae0
Subject(s) - reflux , medicine , bolus (digestion) , gastroenterology , esophageal ph monitoring , gerd , disease
We aimed to determine whether the newborn lamb at term is a valid model for studying gastroesophageal reflux. Seven bottle‐fed lambs, ages 2 to 3 days, underwent esophageal multichannel intraluminal impedance‐pH monitoring (MII‐pH). A total of 196 reflux episodes were recorded, including 73% alkaline and 27% weakly acidic. No acid refluxes were observed. Median bolus clearance time was 4 seconds (3; 5.5), and proximal reflux extent was 35% (26). This first report of MII‐pH in the newborn mammal sets the foundations for future studies with physiological and clinical relevance to human neonates.