Open AccessPharmacokinetics of Sucralose and Acesulfame‐Potassium in Breast Milk Following Ingestion of Diet Soda
Author(s) -
Rother Kristina I.,
Sylvetsky Allison C.,
Walter Peter J.,
Garraffo H. Martin,
Fields David A.
Publication year - 2018
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000001817
Subject(s) - sucralose , ingestion , medicine , breast milk , pharmacokinetics , meal , breast feeding , endocrinology , zoology , chemistry , biology , biochemistry , pathology , pediatrics
Objective: The aim of this study was to determine sucralose and acesulfame‐potassium (ace‐K) pharmacokinetics in breast milk following maternal ingestion of a diet soda. Methods: Thirty‐four exclusively breast‐feeding women (14 normal‐weight, 20 obese) consumed 12 ounces of Diet Rite Cola, sweetened with 68‐mg sucralose and 41‐mg ace‐K, before a standardized breakfast meal. Habitual non‐nutritional sweeteners intake was assessed via a diet questionnaire. Breast milk was collected from the same breast before beverage ingestion and hourly for 6 hours. Results: Owing to one mother having extremely high concentrations, peak sucralose and acesulfame‐potassium concentrations following ingestion of diet soda ranged from 4.0 to 7387.9 ng/mL (median peak 8.1 ng/mL) and 299.0 to 4764.2 ng/mL (median peak 945.3 ng/mL), respectively. Conclusions: Ace‐K and sucralose transfer into breast milk following ingestion of a diet soda. Future research should measure concentrations after repeated exposure and determine whether chronic ingestion of sucralose and acesulfame‐potassium via the breast milk has clinically relevant health consequences.