Open AccessIntestinal Organoids
Author(s) -
Wallach Thomas E.,
Bayrer James R.
Publication year - 2017
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000001411
Subject(s) - organoid , microbiology and biotechnology , cell culture , stem cell , intestinal mucosa , medicine , biology , genetics
The development of sustainable intestinal organoid cell culture has emerged as a new modality for the study of intestinal function and cellular processes. Organoid culture is providing a new testbed for therapeutic research and development. Intestinal organoids, self‐renewing 3‐dimensional structures comprised intestinal stem cells and their differentiated epithelial progeny allow for more facile and robust exploration of cellular activity, cell organization and structure, genetic manipulation, and vastly more physiologic modeling of intestinal response to stimuli as compared to traditional 2‐dimensional cell line cultures. Intestinal organoids are affecting a wide variety of research into gastrointestinal pathology. The purpose of this review is to discuss the current state‐of‐the‐art and future effect of research using enteroids and colonoids (organoids grown from the small and large intestines, respectively).