Open AccessNecrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants
Author(s) -
Sampath Venkatesh,
Helbling Daniel,
Menden Heather,
Dimmock David,
Mulrooney Neil P.,
Murray Jeffrey C.,
Dagle John M.,
Garland Jeffery S.
Publication year - 2016
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000000988
Subject(s) - medicine , necrotizing enterocolitis , gclc , gstp1 , oxygen radical absorbance capacity , gestational age , gene , pediatrics , genetics , genotype , pregnancy , oxidative stress , biology , antioxidant capacity , downregulation and upregulation
Reactive oxygen species mediate intestinal injury in necrotizing enterocolitis (NEC), and yet the contribution of antioxidant response ( ARE ) gene polymorphisms to NEC risk remains unknown. Premature infants recruited in a multicenter study were genotyped for 6 ARE variants. Among 637 infants, 52 had NEC, and 22 developed surgical NEC. Gestational age <28 weeks ( P < 0.02) and African American race ( P = 0.03) were associated with NEC. The NFE2L2 (rs6721961), SOD2 (rs4880), GSTP1 (rs1695), NQO1 (rs1800566), GCLC (rs17883901), and HMOX1 (rs2071747) variants were not associated with medical or surgical NEC. This study does not support a role for common deleterious ARE variants in NEC.