Open AccessFecal Microbial Therapy
Author(s) -
Merenstein Daniel,
ElNachef Najwa,
Lynch Susan V.
Publication year - 2014
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000000415
Subject(s) - medicine , microbiome , clostridium difficile , fecal bacteriotherapy , human microbiome , intensive care medicine , feces , intestinal microbiome , dysbiosis , clostridium infections , treatment modality , disease , therapeutic modalities , gut microbiome , bioinformatics , gut flora , immunology , microbiology and biotechnology , antibiotics , biology
A rapidly expanding range of diverse human diseases is now associated with perturbations to the gastrointestinal microbiome. Fecal microbial transplant (FMT) has been used with high rates of efficacy to treat gastrointestinal microbiome perturbation associated with recurrent Clostridium difficile infection, and is now being considered for other indications. Here we discuss the gut microbiome, review published and ongoing studies using FMT as a treatment modality for human disease, consider the regulatory aspects of FMT, and outline some factors that should be considered in patients in whom this therapeutic strategy is being contemplated.