Open AccessFat‐Soluble Vitamins in Cystic Fibrosis and Pancreatic Insufficiency
Author(s) -
Bertolaso Chiara,
Groleau Veronique,
Schall Joan I.,
Maqbool Asim,
Mascarenhas Maria,
Latham Norma E.,
Dougherty Kelly A.,
Stallings Virginia A.
Publication year - 2014
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000000272
Subject(s) - medicine , endocrinology , osteocalcin , vitamin , cystic fibrosis , fat soluble vitamin , placebo , vitamin e , retinol , vitamin d and neurology , dietary reference intake , alkaline phosphatase , antioxidant , biochemistry , nutrient , chemistry , organic chemistry , pathology , alternative medicine , enzyme
Objectives: The aim of the study was to assess the impact of LYM‐X‐SORB (LXS), an organized lipid matrix that has been shown to be absorbable without pancreatic enzyme therapy on fat‐soluble vitamin status in children with cystic fibrosis (CF) and pancreatic insufficiency (PI). Methods: Children with CF and PI were randomized to daily LXS or an isocaloric placebo comparison supplement for 12 months. Serum vitamins A (retinol), D (25‐hydroxyvitamin D[25D]), E (α‐tocopherol, α‐tocopherol:cholesterol ratio), and K (percentage of undercarboxylated osteocalcin [%ucOC] and plasma proteins induced by vitamin K absence factor II [PIVKA II]) were assessed at baseline and 12 months. Dietary intake was determined using 3‐day weighed food records and supplemental vitamin intake by a comprehensive questionnaire. Results: A total of 58 subjects (32 boys, age 10.3 ± 2.9 years [mean ± standard deviation]) with complete serum vitamin, dietary and supplemental vitamin data were analyzed. After adjusting for dietary and supplemental vitamin intake, serum retinol increased 3.0 ± 1.4 μg/dL (coefficient ± standard error) (adjusted R 2 = 0.02, P = 0.03) and vitamin K status improved as demonstrated by a decreased percentage of undercarboxylated osteocalcin of −6.0% ± 1.6% by 12 months (adjusted R 2 = 0.15, P < 0.001). These changes occurred in both the LXS and placebo comparison groups. No changes in serum 25D or α‐tocopherol were detected. Both nutrition interventions increased caloric intake a mean of 83 ± 666 kcal/day by 12 months. Conclusions: Vitamins A and K status improved, whereas vitamins D and E status was unchanged during 12 months of LXS and isocaloric placebo comparison supplement in children with CF and PI.