Palmitate Activates Insulin Signaling Pathway in Pancreatic Rat Islets | Zendy

Maria Fernanda Rodrigues Graciano | Zendy; Tatiane C.A. Nogueira | Zendy; Carla Roberta de Oliveira Carvalho | Zendy; Rui Curi | Zendy; Ângelo Rafael Carpinelli | Zendy

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Palmitate Activates Insulin Signaling Pathway in Pancreatic Rat Islets

Author(s) -

Maria Fernanda Rodrigues Graciano,

Tatiane C.A. Nogueira,

Carla Roberta de Oliveira Carvalho,

Rui Curi,

Ângelo Rafael Carpinelli

Publication year - 2009

Publication title -

pancreas

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.061

H-Index - 104

eISSN - 1536-4828

pISSN - 0885-3177

DOI - 10.1097/mpa.0b013e31819e65d1

Subject(s) - pancreatic islets , irs1 , medicine , phosphatidylinositol , irs2 , endocrinology , phosphorylation , signal transduction , insulin receptor , tyrosine phosphorylation , kinase , chemistry , insulin receptor substrate , insulin , biology , biochemistry , islet , insulin resistance

To investigate the action of palmitate on insulin receptor (IR) signaling pathway in rat pancreatic islets. The following proteins were studied: IR substrate-1 and -2 (IRS1 and IRS2), phosphatidylinositol 3-kinase, extracellular signal-regulated protein kinase-1 and -2 (ERK1/2), and signal transducer and activator of transcription 3 (STAT3).

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