Elevated Expression Level of MicroRNA-196a Is Predictive of Intestinal-Type Intraductal Papillary Mucinous Neoplasm of the Pancreas | Zendy

Teppei Aso | Zendy; Takao Ohtsuka | Zendy; Koji Tamura | Zendy; Noboru Ideno | Zendy; Hiroshi Kono | Zendy; Yosuke Nagayoshi | Zendy; Kenoki Ohuchida | Zendy; Junji Ueda | Zendy; Shunnichi Takahata | Zendy; Koji Shindo | Zendy; Shinichi Aishima | Zendy; Yoshinao Oda | Zendy; Kazuhiro Mizumoto | Zendy; Masao Tanaka | Zendy

Open Access

Elevated Expression Level of MicroRNA-196a Is Predictive of Intestinal-Type Intraductal Papillary Mucinous Neoplasm of the Pancreas

Author(s) -

Teppei Aso,

Takao Ohtsuka,

Koji Tamura,

Noboru Ideno,

Hiroshi Kono,

Yosuke Nagayoshi,

Kenoki Ohuchida,

Junji Ueda,

Shunnichi Takahata,

Koji Shindo,

Shinichi Aishima,

Yoshinao Oda,

Kazuhiro Mizumoto,

Masao Tanaka

Publication year - 2014

Publication title -

pancreas

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.061

H-Index - 104

eISSN - 1536-4828

pISSN - 0885-3177

DOI - 10.1097/mpa.0000000000000042

Subject(s) - intestinal metaplasia , pancreas , intraductal papillary mucinous neoplasm , medicine , pancreatic cancer , microrna , cdx2 , pathology , mucin 2 , gastroenterology , real time polymerase chain reaction , cancer , biology , gene expression , gene , homeobox , biochemistry

Aberrant expression of several microRNAs (miRs) has been reported in various neoplasms including intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. MicroRNA-196a (miR-196a) is up-regulated in Barrett esophagus (characterized by intestinal metaplasia) and in colorectal cancer; this relationship between intestinal characteristics and miR-196a might also be applicable to intestinal-type IPMNs. The aim of this study was to evaluate whether intestinal-type IPMNs can be discriminated from non-intestinal-type IPMNs by the expression level of miR-196a in tissue and pancreatic juice samples.

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