Open AccessRole of hemoglobin/heme scavenger protein hemopexin in atherosclerosis and inflammatory diseases
Author(s) -
Niyati Mehta,
Srinivasa T. Reddy
Publication year - 2015
Publication title -
current opinion in lipidology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.412
H-Index - 124
eISSN - 1473-6535
pISSN - 0957-9672
DOI - 10.1097/mol.0000000000000208
Subject(s) - hemopexin , heme , oxidative stress , heme oxygenase , experimental autoimmune encephalomyelitis , proinflammatory cytokine , inflammation , immunology , chemistry , hemoglobin , medicine , biochemistry , enzyme
Hemoglobin and its scavenger proteins haptoglobin and hemopexin (Hx) associate with HDL and influence the inflammatory properties of HDL. Moreover, HDL from Hx-null mice is proinflammatory. In addition, Hx deficiency is implicated in a number of other inflammatory diseases such as septic shock and experimental autoimmune encephalomyelitis. This article highlights studies that demonstrate novel insights into the physiological protective role of Hx in inflammatory diseases.