Open AccessADAMTS13 and von Willebrand factor interactions
Author(s) -
Catherine B. Zander,
Wenjing Cao,
X. Long Zheng
Publication year - 2015
Publication title -
current opinion in hematology/current opinion in hematology, with evaluated medline
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 97
eISSN - 1080-8213
pISSN - 1065-6251
DOI - 10.1097/moh.0000000000000169
Subject(s) - adamts13 , von willebrand factor , disintegrin , thrombotic thrombocytopenic purpura , metalloproteinase , adamts , thrombospondin , chemistry , autoantibody , platelet , microbiology and biotechnology , immunology , biochemistry , antibody , matrix metalloproteinase , biology
ADAMTS13 is a zinc-containing metalloprotease that cleaves von Willebrand factor (VWF). Deficiency of plasma ADAMTS13 activity is accountable for a potentially fatal blood disorder thrombotic thrombocytopenic purpura (TTP). Understanding of ADAMTS13-VWF interaction is essential for developing novel treatments to this disorder.