Open AccessEosinophils in infection and intestinal immunity
Author(s) -
Simon P. Hogan,
Amanda Waddell,
Patricia C. Fulkerson
Publication year - 2013
Publication title -
current opinion in gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.165
H-Index - 83
eISSN - 1531-7056
pISSN - 0267-1379
DOI - 10.1097/mog.0b013e32835ab29a
Subject(s) - immunology , eosinophil , ulcerative colitis , immune system , innate immune system , inflammatory bowel disease , proinflammatory cytokine , major basic protein , mucosal immunology , eosinophil cationic protein , medicine , hygiene hypothesis , immunity , biology , microbiology and biotechnology , inflammation , disease , pathology , asthma
Inflammatory bowel diseases (IBDs, e.g., Crohn's disease and ulcerative colitis) are thought to be a consequence of an uncontrolled inflammatory response against luminal antigens, including commensal bacteria. The observed link between eosinophil levels and severity and remission rates in IBD has led to speculation that eosinophils may contribute to the antimicrobial inflammatory response in IBD.