Open AccessRelationship of and cross-talk between physical and biologic properties of the glomerulus
Author(s) -
R. Tyler Miller,
Paul A. Janmey
Publication year - 2015
Publication title -
current opinion in nephrology and hypertension/current opinion in nephrology and hypertension, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 95
eISSN - 1080-8221
pISSN - 1062-4821
DOI - 10.1097/mnh.0000000000000138
Subject(s) - lysyl oxidase , myofibroblast , fibrosis , extracellular matrix , cytoskeleton , pathology , microbiology and biotechnology , cell , cell type , disease , matrix (chemical analysis) , intermediate filament , chemistry , biology , medicine , biochemistry , chromatography
Cells and tissues must respond to physical stresses. Cells exist in an elastic environment determined by their matrix, matrix contacts, cell-cell contacts, and cytoskeletal structure. We discuss the determinants of the elastic environment of cells and its potential roles in glomerular disease.