Purinergic Autocrine Regulation of Mechanosensitivity and Serotonin Release in a Human EC Model | Zendy

Andrómeda Liñán-Rico | Zendy; Jacqueline E. Wunderlich | Zendy; Iveta Grants | Zendy; Wendy L. Frankel | Zendy; Jianjing Xue | Zendy; Kent C. Williams | Zendy; Alan Harzman | Zendy; Joshua T. Enneking | Zendy; Helen J. Cooke | Zendy; Fievos L. Christofi | Zendy

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Purinergic Autocrine Regulation of Mechanosensitivity and Serotonin Release in a Human EC Model

Author(s) -

Andrómeda Liñán-Rico,

Jacqueline E. Wunderlich,

Iveta Grants,

Wendy L. Frankel,

Jianjing Xue,

Kent C. Williams,

Alan Harzman,

Joshua T. Enneking,

Helen J. Cooke,

Fievos L. Christofi

Publication year - 2013

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1097/mib.0b013e31829ecf4d

Subject(s) - purinergic receptor , autocrine signalling , serotonin , purinergic signalling , chemistry , microbiology and biotechnology , pharmacology , medicine , biology , biochemistry , receptor , extracellular , adenosine receptor , agonist

Alterations in 5-hydroxytryptamine (HT) signaling in inflamed gut may contribute to pathogenesis of inflammatory bowel diseases. Adenosine 5'-triphosphate (ATP) regulates mucosal-mechanosensory reflexes and ATP receptors are sensitive to mucosal inflammation. Yet, it remains unknown whether ATP can modulate 5-HT signaling in enterochromaffin cells (EC). We tested the novel purinergic hypothesis that ATP is a critical autocrine regulator of EC mechanosensitivity and whether EC expression of ATP-gated P2X3-ion channels is altered in inflammatory bowel diseases.

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