Open AccessColitis and Colon Cancer in WASP-Deficient Mice Require Helicobacter Species
Author(s) -
Deanna D. Nguyen,
Suresh Muthupalani,
Jeremy A. Goettel,
Michelle A. Eston,
Melissa W. Mobley,
Nancy S. Taylor,
Amanda F. McCabe,
Romela Marin,
Scott B. Snapper,
James G. Fox
Publication year - 2013
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1097/mib.0b013e318295fd8f
Subject(s) - helicobacter , colitis , inflammatory bowel disease , helicobacter pylori , immunology , cancer , biology , colorectal cancer , microbiology and biotechnology , medicine , disease , pathology , genetics
Wiskott-Aldrich syndrome protein-deficient patients and mice are immunodeficient and can develop inflammatory bowel disease. The intestinal microbiome is critical to the development of colitis in most animal models, in which Helicobacter spp. have been implicated in disease pathogenesis. We sought to determine the role of Helicobacter spp. in colitis development in Wiskott-Aldrich syndrome protein-deficient (WKO) mice.
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