Open AccessFluorescence Endoscopy of Cathepsin Activity Discriminates Dysplasia from Colitis
Author(s) -
Elias Gounaris,
John R. Martin,
Yasushige Ishihara,
Mohammad W. Khan,
Goo Lee,
Preetika Sinh,
Eric Zongming Chen,
Michael Angarone,
Ralph Weissleder,
Khasharyasha Khazaie,
Terrence A. Barrett
Publication year - 2013
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1097/mib.0b013e318281f3f8
Subject(s) - dysplasia , medicine , colonoscopy , colitis , pathology , chromoendoscopy , gastroenterology , colorectal cancer , cancer
Surveillance colonoscopy using random biopsies to detect colitis-associated cancer (CAC) suffers from poor sensitivity. Although chromoendoscopy improves detection, acceptance in the community has been slow. Here, we examine the usefulness of near infrared fluorescence (NIRF) endoscopy to image molecular probes for cathepsin activity in colitis-induced dysplasia.
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