Open AccessAltered STAT4 Isoform Expression in Patients with Inflammatory Bowel Disease
Author(s) -
Rukhsana Jabeen,
Lucy Miller,
Weiguo Yao,
Sandeep K. Gupta,
Steven J. Steiner,
Mark H. Kaplan
Publication year - 2015
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1097/mib.0000000000000495
Subject(s) - stat4 , inflammatory bowel disease , medicine , ulcerative colitis , pathogenesis , immunology , biomarker , gastroenterology , biopsy , pathology , disease , biology , gene , stat , biochemistry , stat3
Crohn's disease (CD) and ulcerative colitis (UC) are the major forms of inflammatory bowel disease, and pathogenesis involves a complex interplay among genetic, environmental, and immunological factors. We evaluated isoform expression of the IL-12-activated transcription factor STAT4 in children with CD and UC.