Open AccessSkeletal muscle protein metabolism in human heart failure
Author(s) -
Damien M. Callahan,
Michael J. Toth
Publication year - 2013
Publication title -
current opinion in clinical nutrition and metabolic care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.21
H-Index - 111
eISSN - 1473-6519
pISSN - 1363-1950
DOI - 10.1097/mco.0b013e32835a8842
Subject(s) - skeletal muscle , heart failure , wasting , atrophy , phenotype , protein catabolism , muscle atrophy , medicine , sarcopenia , heart disease , disease , endocrinology , biology , bioinformatics , biochemistry , gene , amino acid
This review considers evidence that the clinical condition of heart failure alters skeletal muscle protein synthesis and/or breakdown to promote skeletal muscle wasting and functional decrements that ultimately contribute to the symptomology of the disease.