Open AccessVentilator-induced diaphragmatic dysfunction
Author(s) -
Basil J. Petrof,
Samir Jaber,
Stéfan Matecki
Publication year - 2009
Publication title -
current opinion in critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.212
H-Index - 88
eISSN - 1080-8183
pISSN - 1070-5295
DOI - 10.1097/mcc.0b013e328334b166
Subject(s) - diaphragmatic breathing , medicine , mechanical ventilation , diaphragm (acoustics) , ventilation (architecture) , intensive care medicine , bioinformatics , anesthesia , pathology , biology , mechanical engineering , physics , alternative medicine , acoustics , loudspeaker , engineering
Diaphragmatic function is a major determinant of the ability to successfully wean patients from mechanical ventilation. There is increasing recognition of a condition termed ventilator-induced diaphragmatic dysfunction. The purpose of the present review is to present evidence that mechanical ventilation can itself be a cause of diaphragmatic dysfunction, to outline our current understanding of the cellular mechanisms responsible for this phenomenon, and to discuss the implications of recent research for future therapeutic strategies.
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