Matrix metalloproteinase 1 promoter polymorphisms and risk of myocardial infarction: a case–control study in a Spanish population | Zendy

Pablo RománGarcía | Zendy; Eliécer Coto | Zendy; Julián R. Reguero | Zendy; Jorge B. CannataAndía | Zendy; Íñigo Lozano | Zendy; Pablo Avanzas | Zendy; César Morı́s | Zendy; Isabel Rodrı́guez | Zendy

Open Access

Matrix metalloproteinase 1 promoter polymorphisms and risk of myocardial infarction: a case–control study in a Spanish population

Author(s) -

Pablo RománGarcía,

Eliécer Coto,

Julián R. Reguero,

Jorge B. CannataAndía,

Íñigo Lozano,

Pablo Avanzas,

César Morı́s,

Isabel Rodrı́guez

Publication year - 2009

Publication title -

coronary artery disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.504

H-Index - 62

eISSN - 1473-5830

pISSN - 0954-6928

DOI - 10.1097/mca.0b013e32832fa9cf

Subject(s) - medicine , odds ratio , haplotype , confidence interval , linkage disequilibrium , genotype , myocardial infarction , case control study , allele , gastroenterology , population , genetics , gene , biology , environmental health

Inherited and acquired risk factors contribute to the development of the atherosclerotic lesion and its most common clinical manifestation, myocardial infarction (MI). Multiple studies have suggested a role for matrix metalloproteinases (MMPs) in atherosclerosis, and several functional polymorphisms in the MMP-1 gene have been linked to the risk of MI. The aim of this study was to evaluate the association between MMP-1 promoter polymorphisms and early MI in a Spanish cohort.

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