Open AccessIn Vitro Testing of a Novel Blood Pump Designed for Temporary Extracorporeal Support
Author(s) -
David Spurlock,
David N. Ranney,
Emilia M. Fracz,
Daniel E. Mazur,
Robert H Bartlet,
Jonathan W. Haft
Publication year - 2012
Publication title -
asaio journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 66
eISSN - 1538-943X
pISSN - 1058-2916
DOI - 10.1097/mat.0b013e318245d356
Subject(s) - peristaltic pump , pulsatile flow , centrifugal pump , ventricular assist device , afterload , suction , preload , thrombogenicity , micropump , extracorporeal membrane oxygenation , heart lung machine , materials science , extracorporeal , extracorporeal circulation , biomedical engineering , impeller , bandwidth throttling , hemodynamics , cardiology , medicine , anesthesia , gas compressor , mechanical engineering , engineering , surgery , heart failure , thrombosis , nanotechnology
Extracorporeal blood pumps are used as temporary ventricular assist devices or for extracorporeal membrane oxygenation. The ideal pump would be intrinsically self-regulating, carry no risk of cavitation or excessive inlet suction, be afterload insensitive, and valveless thus reducing thrombogenicity. Currently used technology, including roller, centrifugal, and pneumatic pulsatile pumps, does not meet these requirements. We studied a nonocclusive peristaltic pump (M-Pump) in two mock circulatory loops and compared the performance to a frequently used centrifugal pump and a modified prototype of the M-Pump (the BioVAD). The simple resistance loop consisted of the investigated pump, a fixed height reservoir at 150 mm Hg, and a variable inflow reservoir. The pulsatile circulation used a mock patient simulator with adjustable resistance elements connected to a pneumatic pulsatile pump. The M-Pump intrinsically regulated flow with changing preload, was afterload insensitive, and did not cavitate, unlike the centrifugal pump. The BioVAD also demonstrated these features and could augment output with the use of vacuum assistance. A nonocclusive peristaltic pump may be superior for short-term extracorporeal circulatory assist by mitigating risks of excessive inlet suction, afterload sensitivity, and thrombosis.