Open AccessUnraveling the Complexities of SIRT1-Mediated Mitochondrial Regulation in Skeletal Muscle
Author(s) -
Andrew Philp,
Simon Schenk
Publication year - 2013
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/jes.0b013e3182956803
Subject(s) - skeletal muscle , mitochondrion , microbiology and biotechnology , chemistry , neuroscience , biology , endocrinology
Sirtuin 1 (SIRT1) is a purported central regulator of skeletal muscle mitochondrial biogenesis. Herein, we discuss our recent work using conditional mouse models, which highlight the complexities of SIRT1 biology in vivo, and question the role of SIRT1 in regulating mitochondrial function and mitochondrial adaptations to endurance exercise. Furthermore, we discuss the possible contribution of proposed SIRT1 substrates to muscle mitochondrial biogenesis.