Open AccessSevere Obesity
Author(s) -
Joseph A. Houmard,
Walter J. Pories,
G. Lynis Dohm
Publication year - 2012
Publication title -
exercise and sport sciences reviews
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/jes.0b013e31825d53fc
Subject(s) - obesity , medicine , severe obesity , endocrinology , bioinformatics , physiology , psychology , biology , weight loss
Severe obesity is increasing at a disproportionate rate compared with milder grade obesity. Our research group has obtained evidence indicative of an "obesity metabolic program" in skeletal muscles of severely obese individuals, which may be determined genetically or epigenetically. We believe that this represents a paradigm shift in thinking about metabolic regulation in obesity.