Open AccessThe MyomiR Network in Skeletal Muscle Plasticity
Author(s) -
John J. McCarthy
Publication year - 2011
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/jes.0b013e31821c01e1
Subject(s) - microrna , skeletal muscle , biology , gene expression , plasticity , regulation of gene expression , neuroscience , microbiology and biotechnology , muscle fibre , mechanism (biology) , gene , genetics , anatomy , philosophy , physics , epistemology , thermodynamics
MicroRNA (miRNA) are a class of noncoding RNA involved in regulating gene expression by a posttranscriptional mechanism. Based on work from our laboratory, this review explores the hypothesis that a recently described muscle-specific miRNA, myomiR, network has a central role in the regulation of skeletal muscle plasticity by coordinating changes in fiber type and muscle mass in response to altered contractile activity.