Open AccessMeasurement of Haemophilus Influenzae Type A Capsular Polysaccharide Antibodies in Cord Blood Sera
Author(s) -
Daniel S. Schmidt,
Kathryn T. Bieging,
Patricia Gómez-de-León,
Alberto Villaseñor-Sierra,
Jaime Inostroza,
John B. Robbins,
Rachel Schneerson,
George M. Carlone,
Sandra Romero-Steiner
Publication year - 2012
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e31825ab166
Subject(s) - antibody , cord blood , haemophilus influenzae , microbiology and biotechnology , immunology , immune system , immunoglobulin g , haemophilus , medicine , virology , biology , bacteria , antibiotics , genetics
We measured anti-Haemophilus influenzae type a capsular polysaccharide serum immunoglobulin G antibodies in cord blood sera from Mexican (n = 68) and Chilean mothers (n = 72) by enzyme-linked immunosorbent assay. Measurable antibodies were found in 79.3% of samples. Immunoglobulin G antibodies correlated with serum bactericidal activity (r = 0.66). This enzyme-linked immunosorbent assay can be used for the evaluation of adaptive immune responses to Haemophilus influenzae type a and serosurveillance studies in populations at risk.