Open AccessNasopharyngeal Lactate Dehydrogenase Concentrations Predict Bronchiolitis Severity in a Prospective Multicenter Emergency Department Study
Author(s) -
Jonathan M. Mansbach,
Pedro A. Piedra,
Federico R. Laham,
Alexander J. McAdam,
Sunday Clark,
Ashley F. Sullivan,
Carlos A. Camargo
Publication year - 2012
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e3182565eae
Subject(s) - bronchiolitis , lactate dehydrogenase , medicine , prospective cohort study , emergency department , multicenter study , gastroenterology , immunology , biology , respiratory system , biochemistry , enzyme , randomized controlled trial , psychiatry
We reexamined the finding of an inverse relationship between values of nasopharyngeal lactate dehydrogenase, a marker of the innate immune response, and bronchiolitis severity. In a prospective, multicenter study of 258 children, we found in a multivariable model that higher nasopharyngeal lactate dehydrogenase values in young children with bronchiolitis were independently associated with a decreased risk of hospitalization.