Nasopharyngeal Lactate Dehydrogenase Concentrations Predict Bronchiolitis Severity in a Prospective Multicenter Emergency Department Study | Zendy

Jonathan M. Mansbach | Zendy; Pedro A. Piedra | Zendy; Federico R. Laham | Zendy; Alexander J. McAdam | Zendy; Sunday Clark | Zendy; Ashley F. Sullivan | Zendy; Carlos A. Camargo | Zendy

Open Access

Nasopharyngeal Lactate Dehydrogenase Concentrations Predict Bronchiolitis Severity in a Prospective Multicenter Emergency Department Study

Author(s) -

Jonathan M. Mansbach,

Pedro A. Piedra,

Federico R. Laham,

Alexander J. McAdam,

Sunday Clark,

Ashley F. Sullivan,

Carlos A. Camargo

Publication year - 2012

Publication title -

the pediatric infectious disease journal

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.028

H-Index - 140

eISSN - 1532-0987

pISSN - 0891-3668

DOI - 10.1097/inf.0b013e3182565eae

Subject(s) - bronchiolitis , lactate dehydrogenase , medicine , prospective cohort study , emergency department , multicenter study , gastroenterology , immunology , biology , respiratory system , biochemistry , enzyme , randomized controlled trial , psychiatry

We reexamined the finding of an inverse relationship between values of nasopharyngeal lactate dehydrogenase, a marker of the innate immune response, and bronchiolitis severity. In a prospective, multicenter study of 258 children, we found in a multivariable model that higher nasopharyngeal lactate dehydrogenase values in young children with bronchiolitis were independently associated with a decreased risk of hospitalization.

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