Open AccessCorticosteroids in the Treatment of Severe Nocardia Pneumonia in Chronic Granulomatous Disease
Author(s) -
Alexandra F. Freeman,
Beatriz E. Marciano,
Victoria Anderson,
Gülbû Uzel,
Christ Costas,
Steven M. Holland
Publication year - 2011
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e318218181d
Subject(s) - chronic granulomatous disease , nocardia , medicine , pneumonia , nocardia infections , antimicrobial , disease , nocardiosis , pathology , immunology , microbiology and biotechnology , bacteria , biology , genetics
Nocardia is 1 of the 5 main pathogens that infect chronic granulomatous disease patients. Despite aggressive antimicrobial therapy, medical treatment is not always successful and surgical resection of infected tissue has been intermittently required. We present 2 chronic granulomatous disease patients with severe Nocardia pneumonia whose pulmonary status worsened despite appropriate antimicrobials, but then improved clinically and radiographically with the addition of corticosteroids.