Open AccessSHOULD HIGHER VANCOMYCIN TROUGH LEVELS BE TARGETED FOR INVASIVE COMMUNITY-ACQUIRED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS INFECTIONS IN CHILDREN?
Author(s) -
Natalia Jiménez-Truque,
Isaac Thomsen,
Elizabeth J. Saye,
C. Buddy Creech
Publication year - 2010
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e3181c52a04
Subject(s) - vancomycin , staphylococcus aureus , methicillin resistant staphylococcus aureus , microbiology and biotechnology , medicine , minimum inhibitory concentration , biology , antibiotics , bacteria , genetics
Methicillin-resistant Staphylococcus aureus isolates with vancomycin minimal inhibitory concentrations (MICs) >or=1.5 microg/mL have been associated with poorer clinical outcomes and treatment failures in adults. We evaluated vancomycin MICs in 71 invasive pediatric community-acquired MRSA isolates from 2004 to 2008, using the E-test micromethod and the E-test macro-method. The modal MIC by micromethod was 1.5 microg/mL, and median vancomycin MICs did not increase over time.