Open AccessPrevalence of Congenital Cytomegalovirus Infection in Nigeria
Author(s) -
Bolajoko O. Olusanya,
Tina M. Slusher,
Suresh B. Boppana
Publication year - 2015
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000000555
Subject(s) - cytomegalovirus , polymerase chain reaction , saliva , confidence interval , medicine , betaherpesvirinae , virology , cytomegalovirus infection , immunology , human immunodeficiency virus (hiv) , human cytomegalovirus , viral disease , herpesviridae , biology , virus , genetics , gene
Dried saliva specimens from 263 neonates in Lagos, Nigeria, were tested for cytomegalovirus (CMV) using real-time polymerase chain reaction. The results for 10 infants (3.8%, 95% confidence interval, 2.1-6.8) were found to be positive. Congenital CMV infection was not associated with any of the demographic or maternal factors including HIV. These data demonstrate the high prevalence of congenital CMV infection and the feasibility of CMV screening by real-time polymerase chain reaction testing.