Open AccessThe Quest for the Best Metric of Antibiotic Use and Its Correlation with the Emergence of Fluoroquinolone Resistance in Children
Author(s) -
Lucia Rosé,
Marissa M. Coulter,
Shan Chan,
Jobayer Hossain,
M. Cecilia Di Pentima
Publication year - 2014
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000000238
Subject(s) - levofloxacin , ciprofloxacin , medicine , antibiotic resistance , antibiotics , drug resistance , metric (unit) , correlation , ofloxacin , intensive care medicine , microbiology and biotechnology , biology , mathematics , operations management , geometry , economics
We evaluated the correlation between fluoroquinolone use, measured by doses administered and days of therapy, with the emergence of ciprofloxacin and levofloxacin resistance among Gram-negative bacilli infections in children hospitalized at one pediatric center between April 2001 and March 2009. Both metrics and drug resistance were highly correlated.