Open AccessPeriostin is Upregulated in Coronary Arteriopathy in Kawasaki Disease and is a Potential Diagnostic Biomarker
Author(s) -
Rebecca Reindel,
Kwang Youn Kim,
Susan C. Baker,
Stanford T. Shulman,
Elizabeth J. Perlman,
Mark W. Lingen,
Cynthia Trevenen,
Anne H. Rowley
Publication year - 2014
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000000233
Subject(s) - kawasaki disease , periostin , diagnostic biomarker , biomarker , medicine , cardiology , diagnostic accuracy , biology , artery , biochemistry , extracellular matrix , microbiology and biotechnology
Periostin was upregulated 11-fold in acute and chronic Kawasaki disease coronary arteries compared with controls (P = 0.003). Kawasaki disease patients had significantly elevated serum periostin values compared with febrile controls (P = 0.0086). There was no relationship between serum periostin values and age, gender or acute phase reactants; there was a relationship between serum periostin and maximal coronary artery Z scores that did not reach significance (P = 0.08). Periostin may prove to be useful as a component of a future diagnostic biomarker panel for Kawasaki Disease.