Open AccessCoronavirus Disease 2019 in Recipient of Allogeneic Hematopoietic Stem Cell Transplantation: Life‐threatening Features Within the Early Post‐engraftment Phase
Author(s) -
Oltolini Chiara,
Guidetti Anna,
Ripa Marco,
Castiglioni Barbara,
Tassan Din Chiara,
Mastaglio Sara,
Canetti Diana,
Monti Giacomo,
Andolina Andrea,
Molinari Chiara,
Poloniato Antonella,
Mastrangelo Andrea,
Ferrante Marica,
Lanzillotta Marco,
Scarpellini Paolo,
Castagna Antonella,
Corradini Paolo,
Ciceri Fabio
Publication year - 2020
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/hs9.0000000000000448
Subject(s) - medicine , tocilizumab , ards , pneumonia , hematopoietic stem cell transplantation , immunology , transplantation , multiple myeloma , disease , lung
China reported a novel coronavirus, phylogenetically related to severe acute respiratory syndrome coronavirus (SARS-CoV), as the causative agent of an outbreak of pneumonia of unknown etiology in Wuhan.WorldHealthOrganization declaredCoronavirus disease 2019 (COVID-19) a global pandemic: nowadays, 4,864,881 cases were reported worldwide, 228,006 in Italy with a 14% mortality rate. Retrospective studies on Chinese patients with pneumonia highlighted that cardiovascular diseases, older age, highC-reactive protein (CRP), interleukin-6 and ferritin, low lymphocytes and secondary infections were predictive of death. COVID-19 features in immunocompromised hematological patients are emerging, but data on allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are still scanty (Table 1). Jin et al reported a case of pneumonia in a male with chronic lymphocytic leukemia successfully treated with chemotherapy,