Open AccessMechanisms, mishaps and manipulation of iron uptake
Author(s) -
Bennett Cavan,
Pasricha SantRayn
Publication year - 2019
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/hs9.0000000000000237
Subject(s) - hepcidin , ferroportin , iron deficiency , hemochromatosis , mononuclear phagocyte system , erythropoiesis , inflammation , medicine , chemistry , endocrinology , immunology , anemia
Insights into mechanisms of iron absorption and systemic iron handling have improved understanding of the pathophysiology of a range of clinical conditions that cause iron deficiency (or iron withholding from the plasma, ‘functional iron deficiency’) or iron overload, and have led to rationally-designed novel therapeutics that may transform management of iron withholding or overload states, some of which are now entering clinical trials. Here, we review recent advances in iron-related physiology, pathology and pharmaceuticals.