Open AccessThe role of innate immunity in MDS pathogenesis
Author(s) -
Sallman David A.,
List Alan
Publication year - 2019
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/hs9.0000000000000217
Subject(s) - pyroptosis , inflammasome , innate immune system , biology , epigenetics , bone marrow , immunology , myeloid , cancer research , inflammation , immune system , genetics , gene
Innate immune activation, driven byMDSC expansion and /or mesenchymal niche cells, may be a disease initiating event in MDS. Cell-extrinsic and-intrinsic signals provoke NLRP3 inflammasome activation that directs an inflammatory cell death, termed pyroptosis, leading to the hallmark pathological features of MDS. Inflammasome activation has potential broad reaching importance as a diagnostic biomarker and therapeutic target in MDS patients.