Open AccessFollicular lymphoma genomics
Author(s) -
Kumar Emil,
Okosun Jessica
Publication year - 2019
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/hs9.0000000000000213
Subject(s) - follicular lymphoma , epigenetics , biology , disease , precision medicine , somatic evolution in cancer , epigenomics , genomics , copy number variation , mechanism (biology) , genetics , reprogramming , dna methylation , gene , bioinformatics , lymphoma , computational biology , genome , medicine , immunology , gene expression , philosophy , epistemology
The genetic landscape of follicular lymphoma (FL) is skewed toward frequent mutations in epigenetic regulators. Divergent clonal evolution from a therapy-evading common progenitor cell is proposed as the predominant mechanism underpinning relapse and transformation. Genomic studies are revealing new disease biomarkers and therapeutic targets, with the promise of achieving a precision medicine approach for subsets of FL patients.