Open AccessGenetic predisposition to chronic lymphocytic leukemia
Author(s) -
Law Philip J.,
Houlston Richard S.
Publication year - 2019
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/hs9.0000000000000194
Subject(s) - chronic lymphocytic leukemia , genetic predisposition , leukemia , medicine , biology , genetics , immunology , gene
Chronic lymphocytic leukemia (CLL) is characterized by having one of the strongest familial risks of any cancer. Genome-wide association studies have identified common variants mapping to over 40 regions of genome that influence the risk of developing sporadic CLL. Sequencing of familial CLL has implicated rare loss-of-function mutations in shelterin complex genes in CLL predisposition. As well as providing new insights in the developmental basis of CLL, the cancer gene discovery initiatives have potential to inform the development of new therapeutic agents.