Open AccessGenetic testing in heritable cardiac arrhythmia syndromes
Author(s) -
John R. Giudicessi,
Michael J. Ackerman
Publication year - 2013
Publication title -
current opinion in cardiology/current opinion in cardiology, with evaluated medline
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.826
H-Index - 78
eISSN - 1080-787X
pISSN - 0268-4705
DOI - 10.1097/hco.0b013e32835b0a41
Subject(s) - genetic testing , medicine , disease , cardiac arrhythmia , long qt syndrome , sudden cardiac death , bioinformatics , qt interval , biology , atrial fibrillation
In this review, we summarize the basic principles governing rare variant interpretation in the heritable cardiac arrhythmia syndromes, focusing on recent advances that have led to disease-specific approaches to the interpretation of positive genetic testing results.