Open AccessWomen's Health Initiative clinical trials: potential interactive effect of calcium and vitamin D supplementation with hormonal therapy on cardiovascular disease
Author(s) -
Xuezhi Jiang,
Matthew Nudy,
Aaron K. Aragaki,
John A. Robbins,
Jo Ann E. Manson,
Marcia L. Stefanick,
David O’Sullivan,
James M. Shikany,
Erin S. LeBlanc,
Anita M. Kelsey,
Jane A. Cauley,
Lisa W. Martin,
Martha E. Payne,
Karen Johnson,
Barbara V. Howard,
Peter F. Schnatz
Publication year - 2019
Publication title -
menopause
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.086
H-Index - 103
eISSN - 1530-0374
pISSN - 1072-3714
DOI - 10.1097/gme.0000000000001360
Subject(s) - medicine , placebo , medroxyprogesterone acetate , women's health initiative , stroke (engine) , myocardial infarction , randomized controlled trial , coronary artery disease , hormone therapy , randomization , estrogen , breast cancer , cancer , postmenopausal women , mechanical engineering , alternative medicine , pathology , engineering
Data in humans and nonhuman primates have suggested a possible synergistic effect of vitamin D and calcium (CaD) and estrogen on the cardiovascular disease (CVD) risk factors. Using randomized trial data we explored whether the effect of menopausal hormone therapy (HT) on CVD events is modified by CaD supplementation.