Open AccessReplication and refinement of linkage of posterior polymorphous corneal dystrophy to the posterior polymorphous corneal dystrophy 1 locus on chromosome 20
Author(s) -
Vivek S. Yellore,
Jeanette C. Papp,
Eric M. Sobel,
Khan Ma,
Sylvia A. Rayner,
Debora B. Farber,
Anthony J. Aldave
Publication year - 2007
Publication title -
genetics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.509
H-Index - 128
eISSN - 1530-0366
pISSN - 1098-3600
DOI - 10.1097/gim.0b013e31803c4dc2
Subject(s) - corneal dystrophy , chromosome 20 , odds ratio , ophthalmology , genetic linkage , locus (genetics) , dystrophy , medicine , biology , genetics , cornea , pathology , chromosome , gene
The study purpose was to identify the genetic basis of posterior polymorphous corneal dystrophy, an autosomal dominant disorder of the corneal endothelium that is associated with the development of corneal edema, necessitating corneal transplantation for visual rehabilitation. Glaucoma also develops in up to 40% of patients with posterior polymorphous corneal dystrophy.
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