The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability | Zendy

Rod A. Lea | Zendy; Natalie Colson | Zendy; Sharon Quinlan | Zendy; John MacMillan | Zendy; Lyn R. Griffiths | Zendy

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The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability

Author(s) -

Rod A. Lea,

Natalie Colson,

Sharon Quinlan,

John MacMillan,

Lyn R. Griffiths

Publication year - 2009

Publication title -

pharmacogenetics and genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.579

H-Index - 140

eISSN - 1744-6880

pISSN - 1744-6872

DOI - 10.1097/fpc.0b013e32832af5a3

Subject(s) - migraine , homocysteine , placebo , medicine , gastroenterology , vitamin b12 , migraine with aura , randomized controlled trial , methylenetetrahydrofolate reductase , genotype , aura , biology , pathology , biochemistry , alternative medicine , gene

Migraine is a prevalent and debilitating disease that may, in part, arise because of disruption in neurovascular endothelia caused by elevated homocysteine. This study examined the homocysteine-lowering effects of vitamin supplementation on migraine disability, frequency and severity and whether MTHFRC677T genotype influenced treatment response.

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