Open AccessAngiotensin-(1-7) and Baroreflex Function in Nucleus Tractus Solitarii of (mRen2)27 Transgenic Rats
Author(s) -
Debra I. Diz,
Marı́a A. Garcı́a-Espinosa,
Patricia E. Gallagher,
Detlev Ganten,
Carlos M. Ferrario,
David B. Averill
Publication year - 2008
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/fjc.0b013e3181734a54
Subject(s) - endocrinology , medicine , baroreflex , angiotensin ii , renin–angiotensin system , solitary nucleus , endogeny , chemistry , receptor , blood pressure , biology , heart rate
Endogenous angiotensin (Ang)-(1-7) enhances, while Ang II attenuates, baroreceptor sensitivity (BRS) for reflex control of heart rate (HR) in Sprague-Dawley (SD) rats. In (mRen2)27 renin transgenic rats [(mRen2)], there is overexpression of the mouse Ren2 gene in brain, leading to elevated Ang II and reduced Ang-(1-7) in brain medullary, and associated with hypertension and impaired BRS.