Open AccessImpact of calcium-channel blockers on right heart function in a controlled model of chronic pulmonary hypertension
Author(s) -
Andreas Zierer,
Rochus K. Voeller,
Spencer J. Melby,
Paul Steendijk,
Marc R. Moon
Publication year - 2009
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1097/eja.0b013e328324b631
Subject(s) - medicine , cardiology , pulmonary artery , ventricle , pulmonary hypertension , contractility , afterload , cardiac output , vasodilation , anesthesia , hemodynamics
Patients with chronic pulmonary hypertension (CPH) who demonstrate pulmonary vasodilation following calcium-channel blocker (CCB) administration are defined as 'responders'. In contrast, 'nonresponders' are patients who do not show such pulmonary vasodilation with CCB therapy. The purpose of this investigation was to study the effects of CCB therapy on right heart mechanics in experimental CCB responders versus CCB nonresponders.