Open AccessComparison of propofol pharmacokinetic and pharmacodynamic models for awake craniotomy
Author(s) -
Martin Soehle,
Christina Wolf,
M. J. Priston,
Georg Neuloh,
Christian G. Bien,
Andreas Hoeft,
Richard K. Ellerkmann
Publication year - 2015
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1097/eja.0000000000000255
Subject(s) - propofol , medicine , anesthesia , craniotomy , pharmacodynamics , pharmacokinetics , bispectral index , surgery
Anaesthesia for awake craniotomy aims for an unconscious patient at the beginning and end of surgery but a rapidly awakening and responsive patient during the awake period. Therefore, an accurate pharmacokinetic/pharmacodynamic (PK/PD) model for propofol is required to tailor depth of anaesthesia.