Open AccessIschemic Heart Disease and Stroke in Relation to Blood DNA Methylation
Author(s) -
Andrea Baccarelli,
Robert O. Wright,
Valentina Bollati,
Augusto A. Litonjua,
Antonella Zanobetti,
Letizia Tarantini,
David Sparrow,
Pantel Vokonas,
Joel Schwartz
Publication year - 2010
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 173
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/ede.0b013e3181f20457
Subject(s) - ischemic stroke , dna methylation , medicine , stroke (engine) , disease , cardiology , biology , ischemia , gene , genetics , gene expression , mechanical engineering , engineering
Epigenetic features such as DNA hypomethylation have been associated with conditions related to cardiovascular risk. We evaluated whether lower blood DNA methylation in heavily methylated repetitive sequences predicts the risk of ischemic heart disease and stroke.