Open AccessSecond-hand Smoke, Cotinine Levels, and Risk of Circulatory Mortality in a Large Cohort Study of Never-Smokers
Author(s) -
Valentina Gallo,
David Neasham,
Luisa Airoldi,
Pietro Ferrari,
Mazda Jenab,
Paolo Boffetta,
Kim Overvad,
Anne Tjønneland,
Françoise ClavelChapelon,
Heiner Boeing,
Valeria Pala,
Domenico Palli,
Salvatore Panico,
Rosario Tumino,
Larraitz Arriola,
Eiliv Lund,
Bas BuenodeMesquita,
Petra H.M. Peeters,
Olle Melander,
Göran Hallmans,
Elio Ríboli,
Rodolfo Saracci,
Paolo Víneis
Publication year - 2010
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 173
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/ede.0b013e3181c9fdad
Subject(s) - cotinine , medicine , hazard ratio , prospective cohort study , proportional hazards model , body mass index , smoke , cohort study , tobacco smoke , confidence interval , cohort , nicotine , environmental health , physics , meteorology
Exposure to second-hand smoke has been shown to be associated with increased cardiovascular mortality in several, but not all, epidemiologic studies. Our aim was to investigate the risk of circulatory death associated with exposure to second-hand smoke in never-smokers in a very large prospective study, the European Prospective Investigation into Cancer and Nutrition. A secondary aim was to use cotinine levels for cross-validating self-reported second-hand smoke exposure.